Silverman was a featured performer on the late-night NBC sketch comedy series between 1993 and 1994. Saturday's show also featured Maroon 5, who performed their hits "Animals" and "Maps." Frontman Adam Levinealso appeared in two sketches.
Check out five highlights from Silverman's SNL hosting debut below.
1. Joan Rivers roasts fellow celebrities in Heaven
Donning a coifed blond wig, a maroon-colored fur jacket, a black top and a chunky pink necklace, Silverman, 43, did her best impression of the late legendary comedienne and host of E!'s Fashion Police, who died at age 81 on Sept. 4, addressing several other deceased famous people.
"My old friend Richard Pryor's here! I can't believe it!" she said. "Even Steve Jobs, right here! Incredible."
Also spotted, Benjamin Franklin, played by Bobby Moynihan.
"Hey Ben, Ben, where'd ya get that outfit?" Silverman-as-Rivers asked. "Forever 1721?"
Levine also made a cameo as late Queen frontman Freddie Mercury, wearing a bright banana yellow outfit, prosthetic teeth and a sweet 'stache.